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通过滴加溴化铜的甲醇溶液 ,6-甲氧基 -2 -丙酰萘在均相体系中回流 ,可高选择性地溴化 ,得到合成非甾体消炎镇痛药萘普生的关键中间体 1-氧代 -1-( 6-甲氧基 -2 -萘基 ) -2 -溴丙烷 ,收率 92 .8%
By dropwise addition of a solution of copper bromide in methanol, 6-methoxy-2-propionyl naphthalene is refluxed in a homogeneous system and can be selectively brominated to give the key to the synthesis of non-steroidal anti-inflammatory analgesic Naproxen The intermediate 1 - oxo - 1 - (6 - methoxy - 2 - naphthyl) -2 - bromopropane, yield 92.8%