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目的探讨高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)和纤维蛋白原(serum fibrinogen level,FIB)浓度变化与冠状动脉的病变程度及冠心病不同类型之间的关系。方法冠状动脉造影患者196例,按照其造影结果分为阴性组106例,单支病变组49例,双支病变组32例和三支病变组9例,hs- CRP采用胶乳增强免疫比浊法测定,FIB采用散色比浊法,并寻找hs-CRP、FIB与冠脉病变的关系。结果多支病变组hs-CRP和FIB浓度明显高于对照组和单支病变组,急性冠脉综合征组明显高于对照组。结论急性冠脉综合征组血中hs-CRP和FIB浓度的升高与冠脉病变的程度有着密切的联系,对冠心病的病变类型具有预测价值。
Objective To investigate the relationship between the changes of high-sensitivity C-reactive protein (hs-CRP) and serum fibrinogen level (FIB) and the degree of coronary artery disease and the different types of coronary heart disease. Methods 196 patients with coronary angiography under the angiography results were divided into negative group of 106 cases, 49 cases of single vessel disease group, 32 cases of double vessel disease group and 9 cases of three vessel disease group, hs-CRP using latex enhanced turbidimetry Determination, FIB using turbidimetry method and looking for hs-CRP, FIB and coronary artery disease. Results The concentrations of hs-CRP and FIB in multi-vessel disease group were significantly higher than those in control group and single vessel disease group. The acute coronary syndrome group was significantly higher than that in control group. Conclusion The increase of hs-CRP and FIB in the blood of patients with acute coronary syndrome is closely related to the degree of coronary artery disease, which has predictive value for the type of coronary heart disease.