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目的:观察大黄素对功能性消化不良(FD)大鼠的促胃肠动力作用及对胃肠激素的影响。方法:雄性8周龄SD大鼠32只,随机分为正常组、模型组、大黄素组、西药组,每组8只。除正常组外,其他各组采用适度夹尾刺激法对大鼠进行造模。模型组及正常组大鼠灌胃蒸馏水,大黄素组和西药组分别给予大黄素、多潘立酮灌胃。7天后测量各组大鼠小肠碳末推进率,测定血清胃动素(MTL)和前列腺素E2(PGE2)水平。结果:与正常组比较,模型组、大黄素组、西药组大鼠体质量和MTL水平显著较低;模型组大鼠胃残留率显著升高,碳末推进率显著降低,差异均有统计学意义(P<0.05)。与模型组比较,大黄素组大鼠MTL和PGE2水平显著升高,胃残留率显著降低,碳末推进率显著升高;西药组胃残留率显著降低,碳末推进率显著升高,差异均有统计学意义(P<0.05)。与西药组比较,大黄素组大鼠MTL和PGE2水平升高的更明显,差异均有统计学意义(P<0.05,P<0.01)。结论:大黄素具有一定促胃肠动力作用,可能与提高胃动素有关,同时因其可提高PGE2水平,具有潜在的胃黏膜保护作用。
Objective: To observe the effect of emodin on gastrointestinal motility and gastrointestinal hormone in rats with functional dyspepsia (FD). Methods: Thirty-two male SD rats of 8 weeks old were randomly divided into normal group, model group, emodin group and western medicine group with 8 rats in each group. In addition to the normal group, the other groups were modeled with moderate tail-tailed stimulation. Rats in model group and normal group were fed with distilled water. Emodin and western medicine groups were given emodin and domperidone respectively. After 7 days, the intestinal carbon advancing rate of each group was measured and the levels of serum motilin (MTL) and prostaglandin E2 (PGE2) were measured. Results: Compared with the normal group, the body weight and MTL level of the model group, the emodin group and the western medicine group were significantly lower. The gastric residual rate in the model group was significantly increased and the carbon removal rate was significantly decreased, the differences were statistically Significance (P <0.05). Compared with the model group, the levels of MTL and PGE2 in emodin group were significantly increased, the gastric residual rate was significantly decreased and the carbon advancing rate was significantly increased; the gastric residual rate in Western medicine group was significantly decreased, while the carbon removal rate was significantly increased There was statistical significance (P <0.05). Compared with Western medicine group, the levels of MTL and PGE2 in emodin group increased more obviously, the differences were statistically significant (P <0.05, P <0.01). CONCLUSION: Emodin has a certain gastrointestinal motility effect, which may be related to the increase of motilin. At the same time, emodin has potential gastric mucosal protective effect because it can increase PGE2 level.