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目的观察马来酸曲美布汀片(双迪)治疗功能性消化不良(FD)的临床疗效。方法102例FD患者随机分为两组,马来酸曲美布汀片组52例,双迪100 mg,3次/日,口服;多潘立酮(吗丁啉)组50例,吗丁啉10 mg,3次/日,口服,疗程均为4周。结果马来酸曲美布汀组有效率88.46%,明显高于多潘立酮组(68.0%)(P<0.05),疗程结束时FD患者早饱、上腹胀痛、嗳气、食欲不振等症状马来酸曲美布汀组明显改善,疗效优于多潘立酮组。治疗过程中两组均未发现明显的不良反应。结论双迪片是治疗FD安全、有效的胃肠动力药物。
Objective To observe the clinical efficacy of trimebutine maleate tablet (Di Di) in the treatment of functional dyspepsia (FD). Methods A total of 102 patients with FD were randomly divided into two groups: 52 cases of trimebutine maleate tablets, 100 mg dihuang tablets per day orally; 50 cases of domperidone group (domperidone), 10 mg domperidone , 3 times / day, oral, treatment are 4 weeks. Results The effective rate of trimebutine maleate group was 88.46%, which was significantly higher than that of domperidone group (68.0%) (P <0.05). At the end of the treatment period, the patients with FD had early fullness, abdominal pain, belching, loss of appetite and other symptoms Trimebutine acid group significantly improved, the effect is better than domperidone group. No significant adverse reactions were found in both groups during the course of treatment. Conclusion Double Di tablets is a safe and effective gastrointestinal motility drug for the treatment of FD.