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贮库型控释制剂例如微囊,其释药速度主要取决于囊心药物结晶的大小及形态,如果制备方法得当,囊心结晶的直径应控制在50～500μm 范围内。作者根据共沉淀法改良得出一种拟乳化溶媒扩散法,举例介绍如下。将布洛芬2.5 g 和丙烯酸树脂(eudra-git)0.25～1.25 g 溶解于乙醇5 ml,醇溶液(25℃)边搅拌边倾入200 ml 含有0～0.025%
Depot controlled release formulations such as microcapsules, the release rate depends mainly on the size and shape of the capsule drug crystals, if the preparation method is appropriate, the diameter of the core crystals should be controlled within the range of 50 ~ 500μm. The authors derive a pseudo-emulsified solvent diffusion method based on the coprecipitation method, as an example below. 2.5 g of ibuprofen and 0.25-1.25 g of eudra-git were dissolved in 5 ml of ethanol. The mixture was poured into 200 ml of an alcohol solution (25 ° C.) containing 0-0.025%