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目的探讨一氧化氮(NO)对高原肺水肿治疗的用量及效果关系。方法64例高原肺水肿患者随机分为3组。常规组(24例)按以往临床常用方法治疗;吸入NO甲组(18例)在常规治疗基础上入院后用BG-951型一氧化氮治疗仪一次性吸入20 ppm NO2 h;吸入NO乙组(22例)在常规治疗基础上入院后用广州军区广州总医院研制的BG-951型一氧化氮治疗仪一次性吸入10 ppm NO 1 h。结果肺部湿性(口罗)音消失时间、肺部X线阴影吸收时间及病程时间吸入NO甲组较乙组及常规组、乙组较常规组均有明显缩短,差异有非常显著性(P<0.01)。结论 吸入NO治疗高原肺水肿疗效可靠,吸入20 ppm NO 2 h用量及疗效最佳。
Objective To investigate the effect of nitric oxide (NO) on the dosage and effect of altitude pulmonary edema. Methods 64 cases of high altitude pulmonary edema were randomly divided into three groups. The conventional group (n = 24) was treated according to the conventional methods. Inhaled NO group (n = 18) was treated with BG-951 nitric oxide treatment instrument (N = 22) were admitted to the hospital on the basis of conventional treatment. The patients were treated with BG-951 nitric oxide treatment device developed by Guangzhou General Hospital of Guangzhou Military Region for a single inhalation of 10 ppm NO for 1 h. Results Lung wet (oral Luo) tone disappear time, pulmonary X-ray shadow absorption time and duration of inhalation of NO A group compared with the B group and the conventional group, B group were significantly shorter than the conventional group, the difference was significant (P <0.01). Conclusion Inhalation of NO for treatment of high altitude pulmonary edema is reliable and the best dosage is achieved with 20 ppm NO 2 h inhalation.