论文部分内容阅读
缺血后再灌注的损害可产生炎性反应,白细胞释放的化学介质在反应中起重要作用。白细胞介素—1(IL—1)是一种强的炎性介质即炎性反应的辅助因子。本研究应用重组人β白细胞介素—1(rhIL—1),选择性IL—1阻滞剂锌原卟啉(Znpp)、抗β白细胞介素—1中和抗体(anti—IL—1β),评价IL—1β对鼠脑缺血后脑水肿的作用。 120只Wistor大鼠麻醉后阻塞右大脑中动脉(MCA)起端,60分钟后开通重灌注缺血区1天,分离出大脑皮质中MCA区,尾状核壳核背侧区(DCP)及膜侧区(VCP),测出含水量。重灌注4分钟后双侧
Ischemic reperfusion injury can produce inflammatory response, the chemical mediators of leukocytes play an important role in the reaction. Interleukin-1 (IL-1) is a potent inflammatory mediator that is a cofactor for inflammatory responses. In this study, recombinant human β-IL-1 (rhIL-1), selective IL-1 blockers zinc protoporphyrin (Znpp), anti-IL- , To evaluate the effect of IL-1β on cerebral edema after cerebral ischemia in rats. A total of 120 Wistor rats were anesthetized and occluded from the middle of the right middle cerebral artery (MCA). After 60 minutes, the ischemic area of the perfusion area was opened for one day. MCA and caudate putamen (DCP) Membrane area (VCP), measured water content. Reperfusion 4 minutes after both sides