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糖尿病肾病(DN)是造成终末期肾病(ESRD)的主要原因之一,众多因素参与并调控了DN的发生发展。目前临床上反应DN的生物标志物主要为尿白蛋白(UAlb),其具有明显的缺陷,因此筛选早期DN生物标志物的研究有助于更好地理解DN的发生及进展机制,从而更好地指导治疗。本文就DN生物标志物研究的最新进展进行介绍。一、DN及其发病机制DN是糖尿病常见和严重的微血管并发症,是糖尿病患者主要的死亡原因之一。30%～50%的1型糖尿病(T1DM)患者及20%的2型糖尿病(T2DM)患者伴随显著的肾功能
Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease (ESRD), and many factors participate in and regulate the occurrence and development of DN. The current clinical biomarkers of DN are urinary albumin (UAlb), which has obvious defects. Therefore, screening of early DN biomarkers helps to better understand the mechanism of DN occurrence and progression and thus better To guide the treatment. This article describes the recent advances in DN biomarker research. First, the DN and its pathogenesis DN is a common and serious diabetic microvascular complications, diabetes is one of the major causes of death. 30% to 50% of patients with type 1 diabetes (T1DM) and 20% of patients with type 2 diabetes (T2DM) have significant renal function