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目的探讨拉莫三嗪联合丙戊酸治疗应用丙戊酸无效的癫痫患者的临床疗效。方法选取2013年2月—2015年2月喀什地区第一人民医院神经内二科收治的丙戊酸治疗无效的癫痫患者130例,随机分为对照组与试验组,各65例。对照组患者予以拉莫三嗪治疗,试验组患者予以拉莫三嗪联合丙戊酸治疗,比较两组癫痫控制效果及不良反应发生情况。结果试验组与对照组总有效率分别为86.15%、56.92%,试验组总有效率高于对照组,差异有统计学意义(P<0.05);试验组与对照组不良反应发生率分别为4.62%、18.46%,试验组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论拉莫三嗪联合丙戊酸治疗应用丙戊酸无效的癫痫患者的临床疗效显著,且不良反应少。
Objective To investigate the clinical efficacy of lamotrigine and valproic acid in the treatment of epilepsy patients with valproate ineffective. Methods A total of 130 patients with epilepsy who were treated with valproate in the Second People’s Hospital of First People’s Hospital of Kashi Prefecture from February 2013 to February 2015 were randomly divided into control group and experimental group with 65 cases in each group. The patients in the control group were treated with lamotrigine. The patients in the test group were treated with lamotrigine plus valproic acid, and the control effect and adverse reactions in the two groups were compared. Results The total effective rates of the experimental group and the control group were 86.15% and 56.92%, respectively. The total effective rate in the experimental group was significantly higher than that in the control group (P <0.05). The incidences of adverse reactions in the experimental and control groups were 4.62 %, 18.46%. The incidence of adverse reactions in the experimental group was lower than that in the control group, with significant difference (P <0.05). Conclusions Lamotrigine and valproic acid are effective in the treatment of epilepsy patients with valproate ineffective, and the adverse reactions are few.