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[目的]了解舟山群岛地区青少年幽门螺杆菌(Hp)感染情况及Hp对常用抗生素的耐药性。[方法]对2008年3月—2011年5月因上消化道疾病在舟山市妇幼保健院住院和门诊治疗的216例青少年进行胃镜检查,并取胃黏膜标本进行Hp培养分离,采用Kirby—Baner药敏纸片对培养分离到的菌株进行抗生素敏感性试验。[结果]216例中成功分离出Hp菌株71例,阳性率为32.87%,其中6～10岁组阳性率为17.86%(15/84),10～14岁组阳性率为30.95%(13/42),14～18岁组阳性率为48.78%(43/90),三组间差异有统计学意义。克拉霉素耐药率为8.45%(6/71)、阿莫西林耐药率为22.54%(16/71)、甲硝唑耐药率为94.37%(67/71)、呋喃唑酮耐药率为16.90%(12/71),而庆大霉素和左氧氟沙星均未检出耐药菌株。[结论]本地区青少年胃黏膜Hp培养阳性率随年龄增长而上升,青少年Hp对甲硝唑和阿莫西林耐药率较高,对克拉霉素和呋喃唑酮耐药率较低,而对庆大霉素和左氧氟沙星无耐药菌株。
[Objective] To understand the infection of Helicobacter pylori (Hp) among adolescents in Zhoushan Archipelago and the resistance of Hp to commonly used antibiotics. [Methods] A total of 216 adolescents with upper gastrointestinal diseases treated in hospital and outpatient department of Zhoushan Maternal and Child Health Hospital from March 2008 to May 2011 were examined by gastroscopy, and gastric mucosa specimens were taken for Hp culture separation. Kirby-Baner Antibiotic susceptibility test was carried out on the strains isolated from the culture by using drug sensitive paper. [Results] The positive rate of Hp strains was 32.87% in 216 cases, of which 17.86% (15/84) were positive in 6 ~ 10 years old group and 30.95% (13.95%) in 10 ~ 14 years old group 42). The positive rate of 14 to 18 years old group was 48.78% (43/90). The difference between the three groups was statistically significant. The rate of clarithromycin resistance was 8.45% (6/71), the rate of amoxicillin resistance was 22.54% (16/71), the metronidazole resistance rate was 94.37% (67/71), the rate of furazolidone resistance was 16.90% (12/71), while no gentamicin and levofloxacin resistant strains were detected. [Conclusion] The positive rate of Hp in gastric mucosa of young people in this area increased with the increase of age. The rate of resistance of Hp to metronidazole and amoxicillin was higher in young people and the rate of resistance to clarithromycin and furazolidone was lower. Resistant to levofloxacin and levofloxacin.