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目的:探讨纳米银凝胶巩固治疗复发性外阴阴道假丝酵母菌病(RVVC)的疗效与安全性。方法:选取深圳市职业病防治院2012年1月-2013年6月妇科就诊RVVC患者28例,采用前瞻性对照方法,将RVVC患者28例随机分为两组各14例,观察组予硝酸咪康唑栓强化治疗后,纳米银凝胶巩固治疗3个月;对照组强化及巩固治疗均使用硝酸咪康唑栓。停药后1、3、6个月各随诊一次,观察患者症状、体征及真菌检查结果。结果:强化治疗后两组患者外阴阴道假丝酵母菌病(VVC)评分差异无统计学意义(P>0.05);随访1个月两组均无复发者;3个月对照组复发率较高,但差异无统计学意义(P>0.05);6个月对照组复发率增高,组间比较差异有统计学意义(P<0.05)。结论:纳米银凝用于RVVC巩固治疗安全有效。
Objective: To investigate the efficacy and safety of nano-silver gel in the treatment of recurrent vulvovaginal candidiasis (RVVC). Methods: 28 cases of gynecological RVVC patients in Shenzhen Occupational Disease Prevention and Treatment Hospital from January 2012 to June 2013 were selected. Twenty-eight patients with RVVC were randomly divided into two groups (n = 14). The patients in the observation group were treated with miconazole nitrate suppositories Intensive treatment, nano-silver gel consolidation treatment for 3 months; control group to strengthen and consolidate the treatment are used miconazole nitrate suppository. After stopping 1, 3, 6 months after each visit, observe the patient’s symptoms, signs and fungal examination results. Results: There was no significant difference in vulvovaginal candidiasis (VVC) score between the two groups after intensive treatment (P> 0.05). No recurrence was found in both groups at one month after follow-up. The recurrence rate of the control group at 3 months was higher , But the difference was not statistically significant (P> 0.05). The recurrence rate of the control group increased after 6 months, with significant difference between the two groups (P <0.05). Conclusion: Nano silver coagulation is safe and effective in the consolidation of RVVC.