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目的探讨乳果糖保留灌肠治疗失代偿期肝硬化的疗效。方法对73例失代偿期肝硬化患者随机分为观察组38例,对照组35例,两组均给予内科综合治疗,观察组同时给予乳果糖每日2次保留灌肠。结果观察组患者血清总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、凝血酶原活动度(PTA)、血氨(NH3)、血清尿素氮(BUN)各项肝功能指标得到进一步改善,主要并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论乳果糖保留灌肠治疗失代偿期肝硬化,可提高临床疗效,减少并发症的发生。
Objective To investigate the efficacy of lactulose retention enema in the treatment of decompensated cirrhosis. Methods Seventy-three patients with decompensated cirrhosis were randomly divided into observation group (n = 38) and control group (n = 35). Both groups were given comprehensive medical treatment. The observation group received lactulose twice a day. Results The levels of serum total bilirubin (TBIL), alanine aminotransferase (ALT), albumin (ALB), prothrombin activity (PTA), blood ammonia (NH3), serum urea nitrogen (BUN) The indicators of liver function were further improved, the incidence of major complications than the control group, the difference was statistically significant (P <0.05). Conclusion Lactulose retention enema treatment of decompensated cirrhosis can improve clinical efficacy and reduce the incidence of complications.