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铝盐佐剂具有极好的安全记录,是各种人类疫苗中唯一获得FDA许可的无机佐剂.据我们所知,目前尚没有关于将其用作化疗药物的递送系统、并系统阐明其结构与载药性能之间关系的研究报道.本研究采用三嵌段共聚物、通过调节反应时间合成了具有可调比表面积和孔径的氢氧化铝(AlOOH)纳米片.AlOOH纳米片的最大比表面积达470 m2/g.其负载化疗药物阿霉素的能力与材料结构密切相关:比表面积和孔径越大,负载化疗药物的量越大.负载有阿霉素的AlOOH纳米片呈现与pH有关的药物释放行为:在pH～5的低pH环境下快速释放,而在pH～7.4的近中性pH下缓慢释放.流式细胞术显示,相比于游离形式的阿霉素,负载在AlOOH纳米片上的阿霉素更易被癌细胞所吞噬.而且负载阿霉素后,与低比表面积的AlOOH纳米片相比,高比表面积的AlOOH纳米片更有利于被癌细胞摄取、诱导癌细胞凋亡和坏死.因此,本研究所合成的AlOOH纳米片有望用作化疗药物递送体系.“,”Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines.However,the exploration of alum nanosheets as chemotherapy drug delivery system,especially the clarification about the relationship between structures and drug loading properties,is totally insufficient.Herein,aluminum hydroxides (AlOOH) nanosheets with tunable specific surface area and pore size were synthesized by adjusting the synthesis time in the presence of triblock copolymers.The obtained materials exhibited the highest surface area about 470 m2/g.The structure-dependent chemotherapy drug loading capability for AlOOH nanosheets was observed:the higher specific surface area and pore size are,the higher amount of chemotherapy drug is loaded.AlOOH nanosheets loaded with doxorubicin showed a pH-dependent sustained release behavior with quick release in low pH about 5 and slow release in pH around 7.4.Doxorubicin-loaded AlOOH nanosheets exhibited much higher cancer cellular uptake efficiency than that in free form by flow cytometry.Moreover,doxorubicin-loaded AlOOH nanosheets with high specific surface area showed an increased cellular uptake efficiency and enhanced ratios of apoptosis and necrosis,compared with those showing low specific surface area.Therefore,AlOOH nanosheets are promising materials as chemotherapy drug delivery system.