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OBJECTIVE How infection of Herpes simplex virus typeⅠ (HSV-1) induces enhancement of autophagy. MEHTODS The wild type HSV-1 strain Kos 1.1 was propagated in Vero cells and purified. SK-N-SH cells seeded in DMEM / F12 were exposed to HSV-1 with 6 h or 12 h