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目的:研究疏血通联合α-硫辛酸治疗糖尿病周围神经病变的临床疗效。方法:选择2009年11月-2010年9月入院治疗的80例经临床诊断确诊为糖尿病周围神经病变患者作为研究对象,严格按照随机分组原则分为治疗组与对照组各40例,其中对照组每日给予α-硫辛酸600mg加入0.9%生理盐水250mL静滴,治疗组在上述基础上每日给予疏血通6mL加入0.9%生理盐水250mL静滴,两组均连续治疗2周。对比两组患者治疗前后症状改善情况,肌电图腓总神经(MNCV)、感觉神经传导速度(SNCV)。结果:两组患者组内相比治疗前后症状有明显改善,传导速度相比治疗前加快,但组间相比治疗组比对照组更加明显。结果具有明显差异性,治疗期间联合治疗组未见明显异常。结论:使用疏血通联合α-硫辛酸治疗糖尿病周围神经病变用药安全,症状改善明显,药效显著,值得临床广泛推广使用。
Objective: To study the clinical efficacy of Shuxuetong combined with α-lipoic acid in the treatment of diabetic peripheral neuropathy. Methods: Eighty patients admitted to hospital from November 2009 to September 2010 were enrolled in this study. Patients diagnosed as diabetic peripheral neuropathy by clinical diagnosis were divided into treatment group (40 cases) and control group (40 cases) randomly. The control group Daily given α-lipoic acid 600mg added 0.9% normal saline 250mL intravenous drip, the treatment group on the basis of the above daily Shu Shuxong 6mL added 0.9% saline 250mL intravenous infusion, two groups were treated for 2 weeks. The improvement of symptoms before and after treatment was compared between the two groups. The MNCV and sensory nerve conduction velocity (SNCV) were measured. Results: Compared with the control group, the two groups had significantly improved symptoms before and after treatment, and the conduction velocity was faster than that before treatment. The results were significantly different, no significant abnormalities in the combination therapy group during treatment. Conclusion: The use of Shuxuetong combined with α-lipoic acid in the treatment of diabetic peripheral neuropathy drug safety, significant improvement in symptoms, significant efficacy, it is widely used in clinical promotion.