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NK/T细胞淋巴瘤(NK/T cell lymphoma,NKTCL)属高度侵袭性肿瘤,预后差,目前尚无明确有效的治疗方案。除了组织形态改变及EBV相关,该病也存在染色体异常、基因突变、信号通路及蛋白表达的异常。国内外学者由此出发,对其发病机制进行了持续的深入研究。本文就NKTCL发病机制的研究进展作一综述。
NK / T cell lymphoma (NK / T cell lymphoma, NKTCL) is a highly aggressive tumor, the prognosis is poor, there is no clear and effective treatment. In addition to histological changes and EBV-related, the disease also exists chromosomal abnormalities, gene mutations, signaling pathways and protein expression abnormalities. Starting from this, domestic and foreign scholars conducted a continuous and in-depth study on their pathogenesis. This article reviews the progress of NKTCL pathogenesis.