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目的:研究慢性肝病患者血清透明质酸(HA),层粘连蛋白(LN)Ⅳ型胶原(ⅣC),Ⅲ型前胶原(PCⅢ)含量与肝组织炎症活动和纤维化程度的关系,及丹参对防治肝纤维化的作用。方法:用放射免疫法测定95例慢性肝病患者血清HA,LN,ⅣC,PCⅢ含量,同时行肝组织活检,对肝组织行炎症分级及纤维化分期,分析上述四项指标含量与肝组织病理分级、分期的关系;对其中10例病理分期为S2或S3的患者使用丹参注射液治疗,并比较分析治疗前后血清HA,LN,ⅣC,PCⅢ含量的变化。结果:上述指标血清含量与慢性肝病发展阶段性一致。在慢性肝炎重度(CHS)与肝硬化(HC)阶段达最高水平。与肝组织炎症坏死及纤维化程度一致,在炎症分级 G4,纤维化分期S4或S3处于最高水平,丹参对肝纤维化的治疗有确切疗效,适用于肝纤维化的基础治疗。结论:血清HA,LN,ⅣC,PCⅢ是反映肝纤维化的有效指标。丹参对防治肝纤维化有确切疗效。
Objective: To investigate the relationship between the levels of serum hyaluronic acid (HA), laminin (Ⅳ) collagen Ⅳ (ⅣC) and type Ⅲ procollagen (Ⅲ) in patients with chronic liver disease and the degree of inflammation and fibrosis in liver tissue, Prevention and treatment of liver fibrosis. Methods: Serum levels of HA, LN, Ⅳ C and PCⅢ in 95 patients with chronic liver disease were determined by radioimmunoassay. At the same time, liver biopsy was performed. Inflammatory grading and fibrosis stage of liver tissue were analyzed. The contents of the above four indexes and histopathological grading , Staging the relationship; of which 10 cases of pathological stage S2 or S3 patients treated with Salvia injection, and compared before and after treatment of serum HA, LN, Ⅳ C, PC Ⅲ content changes. Results: The serum levels of these indicators consistent with the development of chronic liver disease. Highest levels in chronic hepatitis severe and chronic cirrhosis (HC). With the same degree of inflammation, necrosis and fibrosis of liver tissue, the level of inflammation in grading G4, fibrosis stage S4 or S3 at the highest level, the treatment of liver fibrosis Salvia have the exact effect, applicable to the basic treatment of liver fibrosis. Conclusion: Serum HA, LN, Ⅳ C and PC Ⅲ are effective indicators of liver fibrosis. Salvia on the prevention and treatment of liver fibrosis have the exact effect.