目的:探讨结外鼻型T/NK细胞淋巴瘤(ENKL)的临床特点、病理组织学特征及免疫表型。方法:回顾性分析23例ENKL的临床表现、病理组织学特点,采用免疫组化Envision法检测CD3、UCHL1、CD20、CD79a、CD56、GrB,原位杂交方法检测EBER在ENKL中的表达情况。结果:23例ENKL有特征性临床、病理学改变,CD56及EBER阳性表达率达100%。结论:ENKL根据典型的临床表现、病理形态学改变、免疫表型特点及EBER原位杂交阳性能准确诊断。 Objective: To investigate the clinical features, histopathological features and immunophenotype of extranodal nasal type T / NK cell lymphoma (ENKL). Methods: The clinical manifestations and histopathological features of 23 cases of ENKL were retrospectively analyzed. The expression of EBER in ENKL was detected by immunohistochemical Envision assay of CD3, UCHL1, CD20, CD79a, CD56, GrB and in situ hybridization. Results: 23 cases of ENKL had characteristic clinical and pathological changes, and the positive rates of CD56 and EBER were 100%. Conclusion: ENKL is accurately diagnosed based on typical clinical manifestations, pathological changes, immunophenotypic features and positive EBER in situ hybridization.