很多非溃疡性消化不良症(NUD)患者有胃及/或小肠运动及/或感觉的异常,尤其是与胃排空延迟有关。但动力异常与消化不良症状之间在时间上缺乏明确的联系,说明可能有更复杂的机制参与。近10年来,已注意到内源性鸦片样物质对胃肠运动的影响,发现于胃肠道壁的不同区域具有μ型、δ型及κ型鸦片样受体亚型,而Fedotozine(JO 1196)是一种作用于胃肠道κ型鸦片样受体的新药,在动物体内 Many patients with non-ulcerative dyspepsia (NUD) have abnormalities in movement and / or sensation of the stomach and / or the small intestine, especially with delayed gastric emptying. However, the lack of a clear link in time between dyskinesia and dyspeptic symptoms suggests that more complex mechanisms may be involved. In the past decade, the effects of endogenous opioids on gastrointestinal motility have been noted and found to be of type μ, δ and κ opioid receptor subtypes in different regions of the gastrointestinal wall, whereas Fedotozine (JO 1196 ) Is a new drug that acts on the kappa opioid receptors in the gastrointestinal tract in animals