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目的:探讨STAT3基因C1697G(rs4796793)多态性与胃癌发病易感性之间的关系。方法:运用变性高效液相色谱法(denaturing high performance liquid chromatography,DHPLC)检测89例胃癌患者(病例组)和100例健康人群(对照组)的STAT3基因C1697G(rs4796793)多态性,并进行分析。结果:病例组和对照组STAT3基因C1697G(rs4796793)多态性基因型分布频度无显著差异(x~2=2.775,P=0.596)。在调整性别和年龄后,与G/G基因型相比,C/G基因型发生胃癌的危险性上升到1.08(95%CI:0.84-1.44),C/C基因型发生胃癌的危险性上升到1.54(95%CI:0.84-4.395。合并C/G和G/G基因型分析显示,G等位基因发生胃癌的危险性上升到1.69(95%CI:0.37-1.38),STAT3基因C1697G多态性与胃癌发病易感性无相关性(P=0.237)。结论:STAT3基因C1697G(rs4796793)多态性与胃癌易感性不相关。
Objective: To investigate the relationship between polymorphism of STAT3 gene C1697G (rs4796793) and susceptibility to gastric cancer. Methods: The polymorphisms of STAT3 gene C1697G (rs4796793) in 89 gastric cancer patients (case group) and 100 healthy people (control group) were detected by denaturing high performance liquid chromatography (DHPLC) . Results: There was no significant difference in frequency of genotype distribution of STAT3 gene C1697G (rs4796793) between cases and controls (x ~ 2 = 2.775, P = 0.596). After adjusting for gender and age, the risk of gastric cancer in the C / G genotype increased to 1.08 (95% CI: 0.84-1.44) compared with the G / G genotype, and the risk of gastric cancer in the C / C genotype increased To 1.54 (95% CI: 0.84-4.395). Analysis of the combined C / G and G / G genotypes showed that the risk of gastric cancer with the G allele increased to 1.69 (95% CI: 0.37-1.38) There was no correlation between the polymorphism of STAT3 gene and the susceptibility to gastric cancer (P = 0.237) .Conclusion: The polymorphism of STAT3 gene C1697G (rs4796793) is not related to the susceptibility to gastric cancer.