论文部分内容阅读
目的研究维持性血液透析对尿毒症患者的心瓣膜钙化(VC)及胎球蛋白A(Fetuin-A)和C反应蛋白(CRP)水平的影响。方法选取2013年1月-2014年10月收治的200例尿毒症患者作为研究对象,其中发生VC者26例(VC组),未发生VC者174例(对照组)。收集2组患者的基线资料、VC发生率、胎球蛋白A和CRP水平,对VC发生的危险因素进行分析。结果患者是否透析、肾病病程、透析龄、血浆总蛋白(TP)、白蛋白(Alb)、血脂、血肌酐(Scr)、血钙(Ca)、血磷(P)和甲状旁腺素(PTH)等差异均具有统计学意义(P<0.05)。2组患者的Fetuin-A和CRP水平差异具有统计学意义(P<0.05)。患者的年龄、病程、透析龄、Alb、血脂、Ca、P、PTH和CRP与心瓣膜钙化呈正相关(P<0.05),而Fetuin-A与VC发生率呈负相关(P<0.05)。结论维持性血液透析可以降低尿毒症患者的VC发生率和CRP水平,并提高Fetuin-A的水平。
Objective To investigate the effect of maintenance hemodialysis on cardiac valve calcification (VC) and Fetuin-A and C-reactive protein (CRP) levels in uremic patients. Methods A total of 200 uremic patients admitted to our hospital from January 2013 to October 2014 were enrolled. Among them, 26 cases were VC (VC group) and 174 cases were not VC (control group). Baseline data, VC incidence, fetuin A and CRP levels in both groups were collected and risk factors for VC were analyzed. Results The duration of dialysis, the course of nephropathy, the age of dialysis, total protein (TP), albumin (Alb), lipids, serum creatinine, calcium, phosphorus and PTH ) And other differences were statistically significant (P <0.05). The difference of Fetuin-A and CRP between two groups was statistically significant (P <0.05). Age, course of disease, dialysis age, Alb, lipids, Ca, P, PTH and CRP were positively correlated with heart valve calcification (P <0.05), while Fetuin-A was negatively correlated with VC incidence (P <0.05). Conclusion Maintenance hemodialysis can reduce the incidence of VC in patients with uremia and CRP levels, and increase the level of Fetuin-A.