特发性血小板减少性紫癜(ITP)经适当治疗愈后较好,偶有病例无效。作者报道对治疗无效的3例患者,用α干扰素治疗获得成功。1例ITP患者,血小板为2×10~9/L,骨髓显示有较多的巨核细胞,用强的松、长春新碱及苯丁酸氮芥等药及脾切除治疗无效。后每日皮下注射重组α干扰素3 U,共12次。3周后血小板逐渐上升,1周后维持血小板400×10~9/L达4月之久。其他2例为严重ITP,经短程干扰素治疗,未作脾切除,血小板恢复正常。并分别在8年和5年后开始 Idiopathic thrombocytopenic purpura (ITP) after the appropriate treatment of the better, occasional cases ineffective. The authors reported that in 3 patients who did not respond to treatment, treatment with interferon alpha was successful. In 1 patient with ITP, the platelet count was 2 × 10 ~ 9 / L, and the bone marrow showed more megakaryocytes. The treatment with prednisone, vincristine, chlorambucil and other drugs and splenectomy was ineffective. After daily subcutaneous injections of recombinant interferon alpha 3 U, a total of 12 times. After 3 weeks, the platelets gradually increased, maintaining the platelets 400 × 10 ~ 9 / L after 1 week for 4 months. The other 2 cases of severe ITP, short-course interferon treatment, without splenectomy, platelet returned to normal. And begin in eight and five years respectively