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综述了前列腺素、白细胞介素、转化生长因子和肿瘤坏死因子等细胞因子对胰岛素样生长因子 (IGFs)调节系统的影响 ,及其基因分子生物学的调节机制。同时系统激素如生长激素、雌激素、降钙素和甲状旁腺激素等也能影响IGF调节系统。IGF调节系统与成骨细胞和破骨细胞的功能及其成骨和破骨偶联有着密切关系 ,其中IGF可能发挥着核心作用。
The effects of prostaglandin, interleukin, transforming growth factor and tumor necrosis factor cytokines on insulin-like growth factor (IGFs) regulatory system and the regulation of gene molecular biology were summarized. At the same time system hormones such as growth hormone, estrogen, calcitonin and parathyroid hormone can also affect the IGF regulatory system. IGF regulatory system and osteoblasts and osteoclasts function and osteogenesis and osteoclast coupling are closely related, in which IGF may play a central role.