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摘要目的回顾性分析亚洲病人队列中手术切除肺腺癌的表皮生长因子(EGFR)突变状态、主要组织学亚型与CT表现的相关性。材料与方法本研究获得伦理委员会批准并免除书面同意。回顾性分析385例手术切除肺腺癌病人的术前CT表现。分析30个CT征象。采用扩增耐突变系统评价外显子18-21的EGFR突变。应用多元Logistic回归分析判断与EFGR突变状态相关的独立因素。最后纳入模型的因素
Abstract Objective To retrospectively analyze the correlation between the status of EGFR mutation, the major histological subtypes and CT findings in surgical resection of lung adenocarcinoma in Asian patients cohort. Materials and Methods The study was approved by ethics committee and exempted from written consent. A retrospective analysis of 385 cases of surgical resection of lung adenocarcinoma patients with preoperative CT findings. Thirty CT signs were analyzed. EGFR mutations in exons 18-21 were evaluated using an amplification-resistant mutation system. Multivariate logistic regression analysis was used to determine the independent factors associated with the mutation status of EFGR. Finally included in the model of the factors