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目的 为了研究人神经胶质瘤发生中连接蛋白 43的作用。方法 本实验用免疫组化的方法 ,检测了 2 6例不同级别的脑瘤组织中连接蛋白 43的蛋白表达。结果 在正常脑组织星形胶质细胞和良性的脑质细胞瘤连接蛋白 43表达阳性反应 ,在恶性的脑胶质细胞瘤 ,连接蛋白 43明显减弱 ,呈弱性或阴性。结论 人脑胶质细胞肿瘤的发展及恶化程度与其连接蛋白 43蛋白表达有关 ;在癌的多阶段学说 (起始阶段、促癌变阶段、进展阶段 )中 ,连接蛋白 43表达的减少被认为是促瘤变阶段的重要机制。
Objective To investigate the role of connexin43 in the development of human glioma. Methods In this study, immunohistochemistry was used to detect the protein expression of connexin43 in 26 cases of different grades of brain tumor. Results Positive expression of Connexin43 in normal brain astrocytes and benign brain cells was positive. Connexin 43 was significantly weakened and showed weakness or negative in malignant glioma. Conclusions The development and severity of human glioma tumors are related to the expression of connexin 43 protein. The reduction of connexin 43 expression in the multi-stage theory of cancer (initial stage, promotion of carcinogenesis and progression) An important mechanism of tumor stage.