二硫化碳作业女工妊娠经过和妊娠结局的前瞻性研究

来源 :潍坊医学院学报 | 被引量 : 0次 | 上传用户:kaiping56
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目的 探讨二硫化碳(CS2 )对作业女工妊娠经过和妊娠结局的影响及标志女性生殖损伤观察指标的敏感性。方法 从观察对象确诊妊娠时,追踪每名女工的妊娠经过和妊娠结局并监测女工作业地点CS2 浓度。结果 623 次妊娠结局结果表明:①接触组女工自然流产率7.78% 、死胎率1.17% 、新生儿死亡率 14.6‰和出生缺陷率9.7‰,均略高于对照组,但差异均无显著性;早产率 3.11% 、过期产率2.33% 、人工流产率 8.95% 和足月分娩率 74.71% 以及新生儿体重、低体重儿出生率和性比等与对照组比较均无明显差异。新生儿体重有性别差异。②接触组女工妊娠剧吐、贫血、高血压综合征、先兆流产等并发症的发生率以及孕龄、孕期产前检查次数和孕期服药等与对照组比较均无明显差异;接触组女工孕期发热(≥38℃)和搬运重物(≥20kg/次)的频率增多(P 值分别为0.019 和0.006)。结论 ①女工在CS2 平均浓度8.67m g/m 3 下工作至孕时平均4.98 年时,对自然流产、死胎死产、新生儿死亡、出生缺陷、早产、过期产、足月产率、新生儿平均体重、低出生体重发生率、性比及妊娠并发症的发生率、孕龄等未见明显影响;②早早孕丢失和妊娠时间较? Objective To investigate the effect of carbon disulfide (CS2) on pregnant women during pregnancy and pregnancy outcomes as well as the sensitivity of female reproductive injury markers. Methods During pregnancy, the pregnancy and pregnancy outcomes of each female worker were tracked and the concentration of CS2 in female workers was monitored. Results 623 pregnancy outcomes showed that: ① The spontaneous abortion rate of female workers in the contact group was 7.78%, the stillbirth rate was 1.17%, the neonatal mortality rate was 14.6 ‰ and the birth defect rate was 9.7 ‰, both of which were slightly higher than those of the control group , But the differences were not significant; the preterm birth rate was 3.11%, the overdue rate was 2.33%, the abortion rate was 8.95%, the full term delivery rate was 74.71%, the birth weight and the birth weight and the sex Compared with the control group, no significant difference. Neonatal gender differences in body weight. ②The incidence of pregnancy complications such as hyperemesis gravidarum, anemia, hypertension syndrome and threatened abortion in pregnant women in contact group were not significantly different from those in control group (≥38 ℃) and carrying heavy objects (≥20kg / time) (P = 0.019 and 0.006, respectively). Conclusions ①Women working at the average concentration of CS2 8.67m g / m 3 average 4.98 years until pregnancy, the spontaneous abortion, stillborn childbirth, neonatal death, birth defects, premature birth, overdue delivery, full-term birth rate , The average weight of newborns, the incidence of low birth weight, sex ratio and the incidence of pregnancy complications, gestational age and other no significant effect; ② early pregnancy loss and pregnancy time?
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