【摘 要】
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Objective: To investigate the different inhibition effects of different sequential usages of microtubule depolymerization drug and polymerization drug on tumor
【机 构】
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Department of Oncology, The No. 2 People’s Hospital of Yibin, Yibin 644000, China;
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Objective: To investigate the different inhibition effects of different sequential usages of microtubule depolymerization drug and polymerization drug on tumor cells. Methods: Three tumor cell lines including MCF-7, SK-OV3, A549 were incubated with paclitaxel (PTX) and/or vinorelbine (NVB) of different concentrations. The cyto-toxicity was exam-ined by MTT test after incubating 72 h. According to different drugs and different sequences added to 96-well tissue culture plates, 5 groups were divided: PTX group (Group 1), NVB group (Group 2), PTX plus NVB group (Group 3), PTX first and NVB 4-h-later group (Group 4), and NVB first and PTX 4-h-later group (Group 5). Drug concentrations were 100% peak plasma concentration (PPC), 50% PPC, 25% PPC, 12.5% PPC, and 6.25% PPC. Results: The inhibition effects on the three tumor cell lines in Group 5 were stronger than those in the other four groups (P 0.1). Conclusion: Using microtubule depolymertzation drug first and then using microtubule polymerization drug has synergic inhibition effect on tumor cells.
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