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目的探讨老年高血压病合并腔隙性脑梗死患者血清内皮素(ET)及高敏C反应蛋白(hs-CRP)的变化及其在发病机制中的作用。方法回顾性研究22例高血压病合并初发腔隙性脑梗死的患者,20例高血压病合并再发腔隙性脑梗死的患者,25例原发性高血压患者和30例健康体检者的血清ET、hs-CRP水平。结果老年腔隙性脑梗死患者初发组和复发组血清ET及hs-CRP水平均高于原发性高血压病组(P<0.01),原发性高血压病组ET水平高于对照组(P<0.01),hs-CRP高于对照组(P<0.05),且复发组ET水平高于初发组(P<0.05)。结论血清ET和hs-CRP可能参与了老年高血压病合并腔隙性脑梗死的发生发展。
Objective To investigate the changes of serum endothelin (ET) and high-sensitivity C-reactive protein (hs-CRP) in elderly patients with hypertension complicated with lacunar infarction and its role in pathogenesis. Methods A retrospective study of 22 patients with essential hypertension complicated by lacunar infarction, 20 hypertensive patients with recurrent lacunar infarction, 25 patients with essential hypertension and 30 healthy subjects Of serum ET, hs-CRP levels. Results The serum levels of ET and hs-CRP in primary lacunar infarction patients and relapsed patients were significantly higher than those in patients with essential hypertension (P <0.01). The ET level in essential hypertension patients was higher than that in control subjects (P <0.01), hs-CRP was higher than that of the control group (P <0.05), and ET level in the recurrence group was higher than that in the initial group (P <0.05). Conclusions Serum ET and hs-CRP may be involved in the occurrence and development of elderly patients with hypertension and lacunar infarction.