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目的 了解三峡库区重庆段移民区宿主动物携带肾综合征出血热病毒状况和自然疫源地类型 ,为库区移民卫生防病工作提供依据。方法 进行现场流行病学调查 (含流行病学资料 ,啮齿类生态和病原检测 )。应用直接免疫荧光和原位杂交技术分别检测宿主HFRSV Ag和HFRSV RNA。结果 在 5个移民区宿主带毒率分别为 19.4%、17.0 %、14 .0 %、13 .7%和 8.5 %。原位核酸分子杂交检测证实 ,5个移民区宿主动物均存在HFRSV RNA。结论 该研究证实这 5个移民区为HFRS的自然疫源地 ,三峡库区成库后水位提升 ,鼠类将大量迁移 ,可能造成HFRS暴发或流行 ,加强移民区灭鼠与防鼠工作十分必要。
Objective To understand the host animal epidemic situation of hemorrhagic fever with renal syndrome (HFRS) and the type of natural foci in the resettlement area of Chongqing area in the Three Gorges Reservoir Area, and provide the basis for the health and disease prevention in the reservoir areas. Methods Epidemiological investigation (including epidemiological data, rodent ecology and pathogen detection) was conducted. Host HFRSV Ag and HFRSV RNA were detected by direct immunofluorescence and in situ hybridization. Results The host virulence rates in the five resettlement areas were 19.4%, 17.0%, 14.0%, 13.7% and 8.5% respectively. In situ hybridization detection of nucleic acid molecules confirmed that HFRSV RNA was present in all the host animals in the five immigrant areas. Conclusions The study confirmed that the five resettlement areas are natural foci of HFRS. After the reservoir reaches the reservoir, the water level in the Three Gorges Reservoir will increase and mice will migrate in large quantities, which may result in the outbreak or epidemic of HFRS. It is necessary to strengthen the anti-rat and rodent prevention work in immigrant areas .