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目的探讨不宁腿综合征的临床特点、病因及治疗措施。方法自1997年1月到2006年3月在同济医院就诊的不宁腿综合征患者17例,询问病史并作全面体验及影像学检查等,10例患者应用氯硝西泮,另外7例患者给予吡贝地尔口服,于治疗前和治疗4周后分别应用国际不宁腿综合征评估量表(IRLS)进行评分。结果药物治疗后多数患者症状均有不同程度的改善,且吡贝地尔组疗效更明显(P<0.01)。结论不宁腿综合征可能是由多巴胺系统功能紊乱引起中枢神经系统兴奋抑制功能失调导致;多巴胺受体激动剂吡贝地尔可使临床症状获得明显改善,不良反应较轻,患者依从性好,但其长期疗效尚有待于进一步观察。
Objective To investigate the clinical features, etiology and treatment of Restless Legs Syndrome. Methods From January 1997 to March 2006, 17 cases of restless legs syndrome were treated in Tongji Hospital. The patients were asked about their medical history and comprehensive experience and imaging examination. Ten cases were treated with clonazepam and the other 7 cases Piripi Er oral administration, before treatment and after 4 weeks of treatment were applied restless legs syndrome evaluation scale (IRLS) score. Results Most of the patients after drug treatment had different degrees of improvement in symptoms, and the effect of piribedil group was more obvious (P <0.01). Conclusions Restless legs syndrome may be caused by dysfunction of central nervous system excited by dysfunction of dopamine system. Propybetizer dopamine receptor agonist can significantly improve the clinical symptoms, mild adverse reactions, patients with good compliance, However, its long-term efficacy remains to be further observed.