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目的探讨间羟胺依照目标剂量靶控输注对老年人腰硬联合麻醉髋关节手术后意识（认知功能）的影响。方法：择期行髋关节手术老年病人40例，年龄65～85岁，体重（42～60kg），身高（152～165cm），ASAⅡ～Ⅲ级，随机分2组（n=20）：生理盐水输注组（0组）和间羟胺输注组（OG组），两组均监测MAP/HR/ECG/Spo2，分别评估麻醉中，术后72小时平均动脉压、心率的改变。采用简易智力状态检查法（MMSE），评估两组老年病人术后72小时认知功能。结果与麻醉前比较，术后48小时内(O组)有3例(15%)出现认知功能障碍，但术后72小时恢复。而（OG组）术后72小时内没有出现认知功能障碍者。结论间羟胺目标剂量靶控输注对老年人腰硬联合麻醉髋关节手术后意识(认知功能)起积极保护作用。“,” Objective To explore the target dose of metaraminol in accordance with target control ed infusion combined spinal-epidural anesthesia in elderly hip consciousness after the operation (cognitive) effect. Methods: 40 patients undergoing elective hip operation in aged patients, age 65~85 years old, weight (42~60kg), height (152~165cm), ASA Ⅱ ~Ⅲ grade, were randomly divided into 2 groups (n=20): normal saline infusion group (group 0) and metaraminol infusion group (OG group), two groups were monitored MAP/HR/ECG/Spo2, respectively, in 72 hours of anesthesia, changes in mean arterial pressure, heart rate after operation. Using mini mental state examination (MMSE), assessment of two groups of elderly patients after 72 hours of cognitive function. Results compared with those before anesthesia, 48 hours after operation (O group) and 3 cases (15%) of cognitive dysfunction, but after 72 hours of recovery. And (group OG) without cognitive impairment after 72 hours. Conclusion metaraminol target dose of target control ed infusion combined spinal-epidural anesthesia in elderly hip consciousness after the operation (cognitive) play a positive protective effect.