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目的观察蒲地蓝消炎口服液联合五维赖氨酸颗粒治疗疱疹性咽峡炎的疗效。方法将84例疱疹性咽峡炎患儿随机分为两组,对照组采用利巴韦林颗粒口服、开喉剑喷口腔等治疗;治疗组在开喉剑喷口腔的基础上采用蒲地蓝消炎口服液联合五维赖氨酸颗粒应用;比较两组有效率及在退热时间、食欲改善时间、疱疹及溃疡消退时间、总疗程时间的差异,并观察两组治疗前后体液免疫指标及各自病程中不良反应。结果对照组总有效率为83.3%,治疗组为97.6%,两组比较差异有统计学意义(P>0.05);对照组组退热时间、食欲改善时间、疱疹及溃疡消退时间、总疗程时间分别为(5.3±2.1)、(3.9±0.5)、(6.8±1.2)、(7.1±0.83)d,观察组分别为(2.5±1.3)、(2.7±0.6)、(4.4±1.5)、(5.3±0.68)d,两组比较差异有统计学意义(P<0.05);两组患儿治疗前Ig G、Ig A、Ig M比较差异未见统计学意义(P>0.05),治疗后两组免疫球蛋白有所上升,但治疗组三种免疫球蛋白含量均高于对照组,差异有统计学意义(P<0.05);两组患者治疗过程中未见明显不良反应。结论蒲地蓝消炎口服液联合五维赖氨酸颗粒治疗疱疹性咽峡炎能调节患儿免疫,可改善症状,缩短疗程,未见明显不良反应。
Objective To observe the efficacy of Po Di Lan anti-inflammatory oral liquid combined with five-dimensional lysine granules in the treatment of herpes angina. Methods Eighty-four cases of herpes simplex angina were randomly divided into two groups. The control group was treated with oral ribavirin granules and laryngeal sphincter. The treatment group was treated with dipyridamole anti-inflammatory Oral liquid combined with five-dimensional lysine particles; comparison of the two groups were effective and in the time of fever, appetite improvement time, herpes and ulcer subsided time, the total duration of treatment differences, and observed before and after treatment of humoral immune indicators and their duration Adverse reactions. Results The total effective rate was 83.3% in the control group and 97.6% in the treatment group, with significant difference between the two groups (P> 0.05). In the control group, the antipyretic time, appetite improving time, herpes and ulcer subsidence time, Were (5.3 ± 2.1), (3.9 ± 0.5), (6.8 ± 1.2) and (7.1 ± 0.83) d in the observation group and were (2.5 ± 1.3), (2.7 ± 0.6) and 5.3 ± 0.68) d, there was significant difference between the two groups (P <0.05). There was no significant difference in Ig G, Ig A and Ig M between the two groups before treatment (P> 0.05) Group immunoglobulin increased, but the three immunoglobulin levels in the treatment group were higher than the control group, the difference was statistically significant (P <0.05); two groups of patients treated with no significant adverse reactions. Conclusion Pudilan anti-inflammatory oral solution combined with five-dimensional lysine granules in the treatment of herpes angina can modulate the immunity of children, which can improve the symptoms and shorten the course of treatment. No obvious adverse reactions were observed.