本文报道用D-氨基半乳糖所致大鼠暴发性肝衰竭作模型,观察人胎肝细胞对其影响。结果显示,腹腔内注射人胎肝细胞悬液和胞质液均能显著提高肝衰竭大鼠的存活率,两者间比较无显著差别。人胎肝细胞质液可减轻中毒大鼠内毒素血症,降低肝内丙二醛水平,阻止肝坏死,促进肝再生。实验结果提示人胎肝细胞治疗肝衰竭可能主要通过胞质液中的生物活性物质起作用。 This article reports a model of fulminant hepatic failure induced by D-galactosamine in rats and observed the effect of human fetal liver cells. The results showed that the intraperitoneal injection of human fetal liver cell suspension and cytosolic fluid can significantly improve the survival rate of rats with hepatic failure, there was no significant difference between the two. Human fetal liver cytoplasm can reduce endotoxemia in poisoned rats, reduce intrahepatic malondialdehyde levels, prevent liver necrosis, and promote liver regeneration. The experimental results suggest that the treatment of liver failure by human fetal liver cells may act mainly through biologically active substances in the cytosol.