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病历摘要男患,5岁。因20甲全部变形、增厚,表面凸凹不平,失去光泽。于1988年7月就诊。患儿出生时20甲全部正常,于生后三个月发现10个指甲相继变成红褐色、增厚,继之10个趾甲也出现同样现象。先从拇指开始,指甲由红褐色至甲下出血最后指(趾)甲脱落。再生后的指甲仍然粗糙,无光泽,增厚,有明显的纵嵴。其母孕期无患病史或服药史。患儿系足月顺产第二胎。第一胎生产时死亡。出生后未发现指甲改变。患儿各生长发育期正常。其父母亲非近亲婚配,无家族遗传性疾病。查体:发育正常,营养中等,
Medical history male suffering, 5 years old. Because 20 A all deformation, thickening, uneven surface, loss of luster. In July 1988 treatment. 20 children born at birth are all normal, three months after birth found 10 nails have become red-brown, thickening, followed by 10 toenails also appear the same phenomenon. Beginning with the thumb, the nails fall from the reddish brown to the last fingernail (A) of the nail. After the regeneration of the nails is still rough, dull, thickening, a clear longitudinal ridge. The mother had no history of pregnancy or medication history. Children with full-term delivery of the second child. The first child dies when it is produced. Nail change was not found after birth. Children with normal growth and development. Their parents are non-relatives of marriage, no family-related hereditary diseases. Physical examination: normal development, moderate nutrition,