论文部分内容阅读
目的:制备葛根素β-环糊精包合物,研究葛根素包合物渗透泵片的制备工艺和体外释药行为。方法:应用饱和水溶液法制备葛根素β-环糊精包合物,利用释药速率与衣膜组分之间的关系预测并设计正交实验优化处方。结果:饱和水溶液法制备包合物包封率为95.35%±1.15%,优化处方聚乙二醇(PEG)和邻苯二甲酸二丁酯(DBP)的用量分别为醋酸纤维素(CA)用量的5%和20%,膜增重量为片芯的6%。结论:正交实验设计并优化葛根素包合物渗透泵片处方的是一种可行的方法,其释放规律符合控释制剂要求。
OBJECTIVE: To prepare β-cyclodextrin inclusion complex of puerarin and to study the preparation process and in vitro release behavior of puerarin inclusion complex osmotic pump. Methods: The inclusion complex of puerarin β-cyclodextrin was prepared by saturated aqueous solution. The relationship between the drug release rate and the components of the film was predicted and the orthogonal test was designed. Results: The encapsulation efficiency of the inclusion complex was 95.35% ± 1.15% by the saturated aqueous solution method. The optimal dosage of polyethylene glycol (PEG) and dibutyl phthalate (DBP) were the dosage of cellulose acetate (CA) Of the 5% and 20%, film weight increase of 6% of the core. Conclusion: Orthogonal experiment design and optimization of puerarin inclusion complex osmotic pump prescription is a viable method, the release of the law in line with the requirements of controlled release formulations.