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目的探讨血清孕酮(P)、妊娠相关蛋白A(PAPP-A)及血管内皮生长因子(VEGF)水平对早期妊娠患者的意义。方法分析2007-05-2010-11东营市东营区人民医院门诊及住院需进行诊治的早期妊娠患者48例,以ELISA法测血清P、VEGF及PAPP-A水平。结果 P水平在正常妊娠、异常宫内妊娠及异位妊娠3组之间差异均有统计学意义(P<0.01);VEGF水平在正常妊娠与其余两组之间差异有统计学意义(P<0.01);而PAPP-A水平在异位妊娠与另外两组之间差异有统计学意义(P<0.05)。将三者联合成式子[VEGF/(PAPP-AP)]检测3组之间均差异有统计学意义(P<0.01)。结论 P、VEGF、PAPP-A对早期妊娠结局的判断均有一定价值,且三者联合测定将进一步提高异常妊娠的诊断率。
Objective To investigate the significance of serum progesterone (P), pregnancy-associated protein A (PAPP-A) and vascular endothelial growth factor (VEGF) in early pregnancy. Methods Analysis of 48 patients with early pregnancy diagnosed and treated in People ’s Hospital of Dongying, Dongying, 2007-05-2010-11, serum levels of P, VEGF and PAPP - A were measured by ELISA. Results The level of P in normal pregnancy, abnormal intrauterine pregnancy and ectopic pregnancy were significantly different between the three groups (P <0.01). There was a significant difference in the levels of VEGF between normal pregnant women and the other two groups (P < 0.01). The PAPP-A level in ectopic pregnancy and the other two groups was significantly different (P <0.05). There was significant difference between the three groups (P <0.01). Conclusions P, VEGF and PAPP-A have some value in judging the outcome of early pregnancy, and the combination of the three tests will further improve the diagnosis rate of abnormal pregnancy.