论文部分内容阅读
用CCl4等攻击Wistar大鼠，致其肝纤维化。后将其随机分为苦杏仁甙（D）、丹参水溶性提取物（F）、冬虫夏草（E）、D加E（G）、秋水仙碱（C）及空白对照（B）组。均持续病因刺激。另设正常对照（A）组。在体预处理60d后，各实验药物组又随机区分为向和未向培养皿中添加药物，继续培养24h后，检测指标变化。结果表明：阳性药秋水仙碱抑制肝细胞摄入[3H]脯氨酸的作用最强；丹参水溶性提取物在病因持续存在条件下，仍能较强地阻抑肝细胞对[3H]脯氨酸的摄入，提示：①该药作用途径可能为多途径的；②可能有直接对抗病因的作用。苦杏仁甙、冬虫夏草的同一药理作用不及上述二药，但二药联用限定某一条件时，其作用可与秋水仙碱相当。
Wistar rats were challenged with CCl4 and the like, causing hepatic fibrosis. They were randomly divided into amygdalin (D), Salvia miltiorrhiza water-soluble extract (F), Cordyceps sinensis (E), D plus E (G), colchicine (C), and blank control (B) groups. Sustained etiological stimulus. Another normal control (A) group was set up. After 60 days of body pretreatment, each experimental drug group was randomly divided into addition of drugs to and without the culture dish, and after 24 hours of continuous culture, changes in the detection index. The results showed that the positive drug colchicine had the strongest effect of inhibiting hepatocyte uptake of [3H]proline; the water-soluble extract of Salvia miltiorrhiza can still strongly inhibit hepatocytes against [3H]pyrene under the condition of persisting etiology. The intake of amino acids suggested that: 1 The route of action of the drug may be multi-pathway; 2 may have a direct effect on the etiology. The same pharmacological effects of amygdalin and cordyceps are less than those of the above two drugs, but when the two drugs are combined to limit a certain condition, the effect may be comparable to that of colchicine.