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目的评价非脊髓灰质炎(脊灰)肠道病毒感染(Non-Poliomyelitis Enteroviruses Infection,n PEI)对口服脊灰减毒活疫苗(Oral Poliomyelitis Attenuated Live Vaccine,OPV)免疫原性的影响。方法电子检索美国国家医学图书馆数据库(National Center for Biotechnology Information,NCBI)、考克兰(Cochrane)协作网图书馆等数据库,将有关nPEI对OPV免疫原性影响的研究纳入分析。使用综述管理(Rev Man)5.1软件进行统计分析。结果共纳入13篇文献,nPEI对接种OPV后血清阳转率影响的相对危险度(Relative Risk,RR)是0.87[95%可信区间(Confidence Interval,CI):0.79~0.97],其中nPEI对接种单价(Monovalent)OPV(mOPV)后阳转率影响的RR是0.69(95%CI:0.63~0.76),对接种三价(Trivalent)OPV(tOPV)后阳转率影响的RR是0.96(95%CI:0.84~1.09);nPEI对肠道疫苗病毒排出率(Vaccine Virus Shedding Rate,VVSR)影响的RR是0.78(95%CI:0.61~1.00),其中nPEI对接种mOPV后VVSR影响的RR是0.54(95%CI:0.45~0.64),对接种t OPV后VVSR影响的RR是1.11(95%CI:0.83~1.46)。结论 nPEI可降低OPV血清型Ⅰ免疫原性的同时,也可降低mOPV的免疫原性。提示制定OPV免疫策略时,应考虑nPEI的因素,如尽量避开nPEI高发季节。
Objective To evaluate the immunogenicity of non-Poliomyelitis Enteroviruses Infection (n PEI) on oral immunogenicity of Oral Poliomyelitis Attenuated Live Vaccine (OPV). Methods Electronic databases such as the National Center for Biotechnology Information (NCBI) and the Cochrane Collaboration Library were searched electronically for the analysis of the effects of nPEI on the immunogenicity of OPV. Use RevMan 5.1 software for statistical analysis. Results A total of 13 articles were included. The relative risk (RR) of nPEI on the seroconversion rate after OPV vaccination was 0.87 [95% confidence interval (CI): 0.79 ~ 0.97] The RR of RR after positive monovalent OPV (mOPV) was 0.69 (95% CI: 0.63-0.76) and the RR of positive gyration rate after vaccination of trivalent OPV (tOPV) was 0.96 (95 % CI: 0.84-1.09). RR of nPEI on Vaccine Virus Shedding Rate (VVSR) was 0.78 (95% CI: 0.61-1.00). The RR of nPEI on VVSR after vaccination with mOPV was 0.54 (95% CI: 0.45-0.64). The RR of VVSR after t OPV vaccination was 1.11 (95% CI: 0.83-1.46). Conclusions nPEI can reduce the immunogenicity of OPV serotype I and reduce the immunogenicity of mOPV. Tip formulation of immunization strategies OPV, nPEI factors should be considered, such as trying to avoid the nPEI high season.