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窖蛋白(caveolin)是分子量为21～24 kD的整合膜蛋白,是胞膜窖(caveolae)的标志性结构分子,其家族成员窖蛋白-1(caveolin-1,Cav-1)参与细胞内许多重要的生命活动.近来研究发现,窖蛋白-1与乳腺上皮细胞转化及乳腺癌的发生密切相关.基质金属蛋白酶(matrix metalloproteinases,MMPs)是基质降解代谢的主要酶类,几乎能降解细胞外基质和基底膜的所有成分,其家族成员明胶酶A(MMP-2)在乳腺癌的浸润和转移过程中起重要作用.新近发现,窖蛋白-1与基质金属蛋白酶-2在胞膜窖中共定位,窖蛋白-1通过抑制基质金属蛋白酶-2的激活来抑制乳腺癌的侵袭和转移,起到肿瘤抑制因子的作用.本文对窖蛋白-1与基质金属蛋白酶-2各自在乳腺肿瘤侵袭转移中的作用及两者关系的研究进行综述.
Caveolin is an integral membrane protein with a molecular mass of 21-24 kD. It is a hallmark structural molecule of caveolae. Its caveolin-1 (Cav-1) is involved in many intracellular Important life activities.Recently, it is found that caveolin-1 is closely related to the transformation of breast epithelial cells and the occurrence of breast cancer.Matrix metalloproteinases (MMPs) are the main enzymes of matrix degradation and metabolism, and can almost degrade the extracellular matrix And all components of the basement membrane, and its family member gelatinase A (MMP-2) plays an important role in the invasion and metastasis of breast cancer.It has recently been found that caveolin-1 and matrix metalloproteinase-2 co-localized in the membrane cellar , Caveolin-1 inhibits the invasion and metastasis of breast cancer by inhibiting the activation of matrix metalloproteinase-2, and plays a role of tumor suppressor factor.In this paper, the expression of caveolin-1 and matrix metalloproteinase-2 in breast tumor invasion and metastasis The role and the relationship between the two studies are reviewed.