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目的 观察慢性肾小球肾炎患者外周血共刺激分子CD2 8/B7的表达特点 ,以期探讨其在肾小球肾炎发病机制中的作用。方法 采用流式细胞仪 ,对 2 5例慢性肾小球肾炎患者和 15例正常对照组外周血CD3、CD4、CD8、CD2 8、CD4CD2 8、CD8CD2 8、B7的表达进行了研究。结果 2 5例慢性肾小球肾炎患者CD3水平与正常对照组相比无明显差异 (P >0 .0 5 ) ,而CD4、CD2 8、CD4CD2 8、CD8CD2 8表达水平显著低于正常对照组 ,CD8、B7表达水平显著高于正常对照组。结论 慢性肾小球肾炎中 ,细胞免疫功能异常 ,尤其是共刺激分子CD2 8/B7异常在其发病过程中起着重要作用。
Objective To observe the expression of CD2 8 / B7, a costimulatory molecule in peripheral blood of patients with chronic glomerulonephritis, and to explore its role in the pathogenesis of glomerulonephritis. Methods The expression of CD3, CD4, CD8, CD28, CD4 CD28, CD8 CD28 and B7 in peripheral blood of 25 patients with chronic glomerulonephritis and 15 normal controls were studied by flow cytometry. Results There was no significant difference in the level of CD3 between 25 patients with chronic glomerulonephritis (P> 0.05) and the levels of CD4 (superscript +) CD8, CD4 (CD28) and CD8 (CD28) CD8, B7 expression was significantly higher than the normal control group. Conclusions Chronic glomerulonephritis has abnormal cellular immunity, especially abnormal CD2 8 / B7 costimulatory molecules play an important role in the pathogenesis.