肺间质纤维化(pulmonary interstitial fibrosis,PF)是一种原因不明、发病机制尚不清楚并且缺乏确实有效治疗手段的致命性弥漫性肺间质疾病。其病理过程包括肺组织的炎性损伤、组织结构破坏及随后发生肺间质细胞积聚的组织修复过程。在这一过程中,肺炎症细胞、肺泡上皮细胞、和肺间质细 Pulmonary interstitial fibrosis (PF) is a deadly diffuse interstitial lung disease of unknown etiology, unclear pathogenesis and lack of effective treatment. The pathological process includes inflammatory damage of lung tissue, destruction of tissue structure and tissue repair process followed by accumulation of pulmonary interstitial cells. During this process, lung inflammatory cells, alveolar epithelial cells, and pulmonary interstitial cells