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目的探讨老年人血清25-羟基维生素D3[25(OH)D3]与MS的相关性。方法选取MS患者65例及健康者62名,测量血压、身高、体重、WC及臀围,检测25(OH)D3、FPG、FIns、TC、TG、HDL-C、LDL-C及血尿酸(SUA),计算WHR、BMI及胰岛素抵抗指数(HOMA-IR)。结果 MS组25(OH)D3水平低于NC组(P<0.05)。按照25(OH)D3≥30ng/ml、20ng/ml≤25(OH)D3<30ng/ml、25(OH)D3<20ng/ml水平分为3组,NC组在各组中所占比例分别为30.6%、27.4%、41.9%;MS组在各组中所占比例分别为4.6%、33.8%、61.6%。MS组25(OH)D3缺乏比例高于NC组(P=0.012)。MS组25(OH)D3水平与BMI、WC、SBP、FPG、HOMA-IR、TG、LDL-C、SUA呈负相关(P<0.05),与WHR、DBP、FIns、TC呈负性线性趋势(P>0.05),与HDL-C呈正性线性趋势(P>0.05)。根据BMI不同水平将MS组分为超重和肥胖亚组,两亚组25(OH)D3水平比较差异无统计学意义。结论正常老年人维生素D水平普遍较低,MS老年患者更低。MS各组分与25(OH)D3水平呈负相关,提示25(OH)D3低水平可能是MS的危险因素。
Objective To investigate the correlation between serum 25-hydroxyvitamin D3 [25 (OH) D3] and MS in the elderly. Methods Totally 65 MS patients and 62 healthy subjects were enrolled in this study. Blood pressure, height, weight, WC and hip circumference were measured. The levels of 25 (OH) D3, FPG, FIns, TC, TG, HDL-C, LDL- SUA), calculate WHR, BMI and insulin resistance index (HOMA-IR). Results The level of 25 (OH) D3 in MS group was lower than that in NC group (P <0.05). According to the level of 25 (OH) D3≥30ng / ml, 20ng / ml≤25 (OH) D3 <30ng / ml and 25 (OH) D3 <20ng / ml, the proportion of NC group in each group was 30.6%, 27.4% and 41.9% respectively. The proportion of MS group in each group was 4.6%, 33.8% and 61.6% respectively. The proportion of 25 (OH) D3 deficiency in MS group was higher than that in NC group (P = 0.012). The level of 25 (OH) D3 in MS group was negatively correlated with BMI, WC, SBP, FPG, HOMA-IR, TG, LDL-C and SUA (P < (P> 0.05), and showed a positive linear trend with HDL-C (P> 0.05). MS groups were divided into overweight and obesity subgroup according to different levels of BMI. There was no significant difference in 25 (OH) D3 between two subgroups. Conclusion The levels of vitamin D in the elderly are generally low and the elderly with MS are lower. MS components and 25 (OH) D3 levels were negatively correlated, suggesting that 25 (OH) D3 low level may be a risk factor for MS.