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目的:观察喹诺酮类抗菌药治疗盆腔炎性疾病的疗效及安全性。方法:70例盆腔炎性疾病患者根据入院先后顺序分为观察组和对照组各35例,观察组患者采用盐酸左氧氟沙星治疗,对照组采用环丙沙星治疗。治疗20 d后,比较两组患者体温、下腹疼痛等各项临床症状体征恢复正常的时间,评价两组临床疗效和药品不良反应发生情况。结果:观察组总有效率为97.14%,明显高于对照组的82.86%(P<0.05)。观察组临床症状体征恢复正常时间均明显短于对照组,差异有统计学意义(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸左氧氟沙星治疗头孢菌素皮试阳性的盆腔炎患者临床疗效较高,能迅速改善患者临床症状体征,且安全性较高。
Objective: To observe the efficacy and safety of quinolone antibacterials in the treatment of pelvic inflammatory disease. Methods: Seventy patients with pelvic inflammatory disease were divided into observation group (35 cases) and control group (35 cases). The observation group was treated with levofloxacin hydrochloride and the control group was treated with ciprofloxacin. After 20 days of treatment, the clinical symptoms and signs such as body temperature and abdominal pain in both groups returned to normal, and the clinical efficacy and adverse drug reactions in both groups were compared. Results: The total effective rate in observation group was 97.14%, which was significantly higher than that in control group (82.86%, P <0.05). The symptoms and signs of observation group returned to normal time were significantly shorter than the control group, the difference was statistically significant (P <0.05). There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusion: Levofloxacin Hydrochloride for the treatment of cephalosporin skin-positive pelvic inflammatory disease patients with high clinical efficacy, can quickly improve the symptoms and signs of patients with high safety.