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目的:研究STAT3和STAT5与Survivin和Ki67蛋白在EB病毒(EBV)相关鼻NK/T细胞淋巴瘤中的表达。方法:用免疫组织化学方法检测25例鼻NK/T细胞淋巴瘤患者病理标本STAT3、STAT5和Sur-vivin、Ki67的表达,并对它们的表达作相关性分析。另取20例慢性鼻窦炎患者的鼻腔黏膜作对照。结果:STAT3在鼻NK/T细胞淋巴瘤和慢性鼻窦炎中的阳性率分别为56%和10%;STAT5阳性率分别为68%和15%,均差异有统计学意义(均P<0.01)。Survivin在鼻NK/T细胞淋巴瘤和慢性鼻窦炎中的表达分别为68%和0;Ki67的表达分别为72%和20%,均差异有统计学意义(均P<0.01)。相关性分析发现STAT3的表达与Survivin和Ki67的表达均成正相关(r=0.428,P<0.05和r=0.704,P<0.01);STAT5的表达与Survivin和Ki67的表达无明显相关。结论:STAT通路可能在鼻NK/T细胞淋巴瘤的发生发展中起重要作用,STAT3可能通过诱导Survivin和Ki67的表达参与鼻NK/T细胞淋巴瘤的形成。
Objective: To investigate the expression of STAT3, STAT5, Survivin and Ki67 in Epstein-Barr virus (EBV) -associated nasal NK / T cell lymphoma. Methods: The expressions of STAT3, STAT5, Survivin and Ki67 were detected by immunohistochemistry in 25 cases of nasal NK / T cell lymphoma and their correlations were analyzed. Another 20 cases of chronic sinusitis in patients with nasal mucosa as a control. Results: The positive rates of STAT3 in nasal NK / T-cell lymphoma and chronic sinusitis were 56% and 10%, respectively. The positive rates of STAT5 were 68% and 15% respectively (all P <0.01) . The expression of Survivin in nasal NK / T cell lymphoma and chronic sinusitis was 68% and 0, respectively. The expression of Ki67 was 72% and 20%, respectively, with significant difference (all P <0.01). Correlation analysis showed that the expression of STAT3 was positively correlated with the expression of Survivin and Ki67 (r = 0.428, P <0.05 and r = 0.704, P <0.01). The expression of STAT5 had no significant correlation with the expression of Survivin and Ki67. Conclusion: STAT pathway may play an important role in the development of nasal NK / T cell lymphoma. STAT3 may be involved in the formation of nasal NK / T cell lymphoma by inducing the expression of Survivin and Ki67.