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目的:探讨血清超敏C-反应蛋白(hs-CRP)和脂蛋白a[LP(a)]等在糖尿病肾病(DN)患者中的变化及意义。方法:98例2型糖尿病(T2DM)患者按尿白蛋白排泄率分SDM组32例、EDM组34例、CDM组32例,对照组30例,测血清hsCRP、LP(a)、PA、ALB含量。结果:各T2DM组与对照组比较,hsCRP、Lp(a)差异均有统计学意义;PA、ALB在CDN较对照组降低并有统计学意义。结论:血清hs-CRP、Lp(a)、ALB、PA水平与DN发生进展有关。
Objective: To investigate the changes and clinical significance of serum hs-CRP and LP (a) in patients with diabetic nephropathy (DN). Methods: 98 patients with type 2 diabetes mellitus (T2DM) were divided into SDM group (32 cases), EDM group (34 cases), CDM group (32 cases) and control group (30 cases). Serum hsCRP, content. Results: The differences of hsCRP and Lp (a) between T2DM group and control group were statistically significant. The levels of PA and ALB in CDN were lower than those in control group. Conclusion: The serum levels of hs-CRP, Lp (a), ALB and PA are related to the progression of DN.