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作者发现乙型脑炎(JE)疫苗(以明胶作稳定剂)可引发两种不同的全身性速发型变态反应。一组儿童出现皮肤和呼吸系统症状(如全身性荨麻疹和喘鸣);而另一组则出现心血管系统症状(如低血压和紫绀)。作者采用Pharmacia CAP系统检测抗牛明胶IgE浓度来研究JE疫苗中明胶与这两种反应的关系。
The authors found that Japanese encephalitis (JE) vaccine, with gelatin as a stabilizer, can elicit two different systemic immediate-onset allergies. One group of children developed skin and respiratory symptoms (such as generalized urticaria and wheezing); while the other group experienced cardiovascular symptoms (such as hypotension and cyanosis). The authors used the Pharmacia CAP system to measure anti-bovine gelatin IgE concentrations to investigate the relationship between gelatin and these two responses in the JE vaccine.