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目的 观察骨基质明胶 ( BMG)在软组织内植入及与金属材料复合骨组织植入后的活性及作用。方法 取兔四肢骨制作 ,并将其植入 5只兔的腹部肌肉中 ,将 BMG与自蔓延钛镍合金复合后植入 3只兔颅骨中进行观察 ,术后 1、2、3、4、8、12周处死动物 ,进行组织学及电镜观察。结果 BMG植入软组织后 ,3～ 4周时可见软骨基质形成 ,但 8周时 BMG和形成物被完全吸收 ;在硬组织植入 1个月左右 ,复合材料在成骨时间及骨的成熟度上均强于单一金属材料 ,3个月左右则无明显差异。结论 BMG具有异位诱导骨形成的能力 ,与自蔓延钛镍合金复合对金属材料与周围组织的早期愈合起较大作用
Objective To observe the activity and role of bone matrix gelatin (BMG) implanted in soft tissue and composite bone tissue implanted with metal material. Methods The rabbit limbs were made and implanted into the abdominal muscles of 5 rabbits. The BMG and self-propagating Ti-Ni alloy were implanted into the skull of 3 rabbits for observation. After 1, 2, 3, 4, Animals were killed at 8 and 12 weeks for histological and electron microscopic observation. Results After BMG implantation, the formation of cartilage matrix was observed at 3 to 4 weeks, but BMG and its formation were completely absorbed at 8 weeks. At 1 month after hard tissue implantation, the bone formation time and bone maturation Are stronger than a single metal material, no significant difference in about 3 months. Conclusion BMG has the ability of ectopic induction of bone formation, and plays a greater role in the early healing of metal materials and surrounding tissues with the self-propagating Ti-Ni alloy composite