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对１００例前列腺增生（ＢＰＨ）患者的前列腺体积、年龄、血清前列腺特异抗原（ＰＳＡ）、抗原密度（ＰＳＡＤ）进行多元回归与相关分析。结果：年龄和前列腺体积均与血清ＰＳＡ浓度显著相关（Ｐ＜０．０１），其中，体积与ＰＳＡ之间和年龄与体积之间具有相关性（Ｐ＜０．００１、Ｐ＜０．０５），而年龄与ＰＳＡ之间无相关性（Ｐ＞０．０５），体积每增加１０ｃｍ３，ＰＳＡ增高０．９μｇ／Ｌ。ＰＳＡＤ不受前列腺体积的影响（Ｐ＞０．０５），有８２％的ＢＰＨ患者在正常范围内，其中２４例ＰＳＡ在４～１０μｇ／Ｌ的患者有１８例ＰＳＡＤ≤０．２。血清ＰＳＡ浓度主要受前列腺体积影响，年龄的影响是通过对体积的影响而间接引起的，ＰＳＡＤ可以消除前列腺体积的影响，在评价ＰＳＡ浓度轻度增高时有更高的特异性。
Prostate volume, age, serum PSA and PSAD in 100 patients with benign prostatic hyperplasia (BPH) were analyzed by multiple regression and correlation analysis. RESULTS: Both age and prostate volume were significantly associated with serum PSA levels (P <0.01), with correlation between volume and PSA and between age and volume (P <0.001, P <0.05) , While there was no correlation between age and PSA (P> 0.05). The volume of PSA increased by 0.9μg / L for every 10cm3 increase. PSAD was not affected by prostate volume (P> 0.05), and 82% of BPH patients were in the normal range. Among them, PSAD≤0.2 in 18 of 24 patients with PSA ranging from 4 to 10 μg / L. Serum PSA concentration is mainly influenced by prostate volume. The effect of age is indirectly caused by the influence on volume. PSAD can eliminate the influence of prostate volume and has higher specificity in assessing mild increase of PSA concentration.