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目的探讨叶酸联合幽门螺杆菌(Hp)根除治疗慢性萎缩性胃炎患者的疗效。方法选取2014年6月至2016年7月锦州市中心医院消化内科门诊收治的86例慢性萎缩性胃炎患者作为研究对象,将其随机分为联合组和常规组,各43例。对照组患者采用常规三联疗法,联合组患者在对照组基础上联合采用叶酸治疗。比较两组患者治疗前后症状评分及血清胃蛋白酶原-Ⅰ(PGI)、胃泌素17(G17)水平,评估治疗效果并观察安全性。结果治疗后,联合组患者症状评分明显低于常规组,血清PGI、G17水平均明显高于常规组,差异均有统计学意义(均P<0.05);联合组患者治疗的总有效率达97.7%,明显高于常规组的76.7%,差异有统计学意义(P<0.05)。结论在慢性萎缩性胃炎患者实施常规三联疗法根除Hp的同时联合采用叶酸治疗,可有效改善症状,提高整体疗效,且安全性较高。
Objective To investigate the efficacy of folic acid combined with Helicobacter pylori (Hp) in the treatment of patients with chronic atrophic gastritis. Methods A total of 86 patients with chronic atrophic gastritis admitted from the Department of Gastroenterology, Jinzhou Central Hospital from June 2014 to July 2016 were selected as study subjects and randomly divided into the combined group and the conventional group, with 43 cases in each group. The control group of patients with conventional triple therapy, combined group of patients in the control group based on the combination of folic acid therapy. The symptom scores, serum pepsinogen-Ⅰ (PGI) and gastrin 17 (G17) levels were compared between the two groups before and after treatment to evaluate the therapeutic effect and observe the safety. Results After treatment, the scores of symptoms in the combined group were significantly lower than those in the conventional group, and the serum levels of PGI and G17 were significantly higher than those in the conventional group (all P <0.05). The total effective rate of the combination group was 97.7 %, Significantly higher than the 76.7% of the conventional group, the difference was statistically significant (P <0.05). Conclusions In patients with chronic atrophic gastritis, conventional triple therapy to eradicate Hp combined with folic acid therapy can effectively improve the symptoms and improve the overall efficacy and safety.