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目的 :研究颅内嗅神经母细胞瘤的临床。方法 :回顾性分析经手术病理证实的颅内嗅神经母细胞瘤 10例。结果 :本组患者平均年龄 3 5 5岁 ,平均病程 10个月 ,首发症状以鼻衄、鼻塞为主 ,头颅CT、MRI显示肿瘤大多位于前颅底 ,有骨质破坏及颅内外沟通。术后 8例随访 2个月～ 4年 ,存活 3例 ,死亡 5例。结论 :颅内嗅神经母细胞瘤极为罕见 ,多伴有鼻部症状 ,常发生于以嗅沟为中心的前颅底 ,一般预后差。手术全切除外加放疗、化疗有助于预后。
Objective: To study the clinical features of intracranial olfactory neuroblastoma. Methods: A retrospective analysis of 10 cases of intracranial olfactory neuroblastoma confirmed by surgery and pathology. Results: The average age of patients in this group was 35 years. The average course of disease was 10 months. The first symptom was epistaxis and nasal congestion. CT and MRI showed that most of the tumors were located in the anterior skull base with the destruction of bone and intracranial and extracranial communication. Eight patients were followed up for 2 months to 4 years, 3 survived and 5 died. CONCLUSIONS: Intracranial olfactory neuroblastoma is extremely rare and often accompanied by nasal symptoms. It often occurs in the anterior skull base with the olfactory groove as its center. The general prognosis is poor. Surgical resection plus radiotherapy, chemotherapy helps prognosis.